Table 2. Details of prostate pathology observed in the cPten -/- S -/-group.
| Animal No. | Age (wks) |
Pathology
|
Remarks | ||
|---|---|---|---|---|---|
| AP | VP | DLP | |||
| 5496 | 9.4 | PIN1 | PIN1 | PIN1 | Few atypical cells (AP), single atypical (hypertrophic, polyploid) |
| cells, some exfoliated (VP, DLP) | |||||
| 5912 | 9.6 | PIN1 | PIN1 | PIN1 | Exfoliation, single atypical cells, focal hyperplasia (AP), single |
| atypical cells, exfoliation (VP), single atypical cells, hypertrophy, | |||||
| exfoliation (DLP) | |||||
| 5927 | 10 | PIN1 | PIN1 | PIN2 | Mainly RS, few PIN1, single atypical cell (AP), single atypical |
| cells (VP), small PIN2 with large atypical cells, no desmoplastic | |||||
| stroma, exfoliation (DLP) | |||||
| 5928 | 10 | RS | PIN1 | PIN2 | Areas of exfoliation, single atypical cells (AP), few atypical cells, |
| exfoliation (DLP) | |||||
| 5812 | 11 | RS | PIN1 | PIN2 | Some exfoliation (AP), few atypical/apoptotic/exfoliated cells |
| (VP), small areas of enlarged (nucleus and cytoplasm) cells, | |||||
| some exfoliation, rare PIN2 (DLP) | |||||
| 5498 | 18.6 | PIN1 | PIN1 | PIN3 | Few atypical cells, exfoliation (AP), few large atypical cells, |
| hypertrophy, exfoliation (VP), PINs with large atypical and | |||||
| apoptotic cells (DLP) | |||||
| 5753 | 19.7 | PIN2 | PIN1 | PIN3 | Small PIN2 (AP), large vacuolized cells filling up the ducts- |
| hypertrophy (AP, DLP), few atypical cells (AP, VP) | |||||
| 5754 | 19.7 | PIN1 | PIN1 | PIN3 | Modest hyperplasia, some exfoliation (AP), few atypical cells, as |
| in other cases such cells can be hyperploid (VP), large atypical | |||||
| cells, some of them are exfoliated, moderate hyperlasia (DLP) | |||||
| 5757 | 19.7 | PIN3 | PIN2 | PIN3 | Few large atypical cells (AP, VP), hyperplasia/hypertrophy (AP, |
| VP, DLP), some apoptosis (DLP) | |||||
| 5774 | 19.7 | PIN1 | PIN1 | PIN3 | Single atypical cells, exfoliation (AP), large atypical cells but no |
| no stratification/piling up (VP), hyperplasia, PIN3, single atypical | |||||
| cells, no desmoplastic reaction (DLP) | |||||
| 5675 | 39.3 | PIN1 | PIN2 | PIN3 | Single atypical cells (AP, VP), areas of hypertrophy (VP), |
| hypertrophy/hyperplasia, some apoptosis, no desmoplasia (DLP) | |||||
| 5678 | 39.3 | PIN1 | PIN2 | PIN3 | Hypertrophy (AP), few large atypical cells (VP), hyperplasia/ |
| hypertrophy (VP, DLP), some apoptosis (DLP) | |||||
| 5679 | 39.3 | PIN1 | PIN1 | PIN3 | Few atypical cells (AP), single atypical and hypertrophic cells |
| (VP), hypertrophy/hyperplasia, some apoptosis (DLP) | |||||
| 5683 | 39.3 | PIN3 | PIN4 | PIN3 | Few large atypical cells/hypertrophy (AP, VP), hyperplasia (VP), |
| apoptosis (VP, DLP) | |||||
| 5681 | 39.4 | PIN3 | PIN4 | PIN3 | Massive exfoliation (AP) |
| 5628 | 54 | PIN3 | PIN3 | PIN4 | Hypertrophy/hyperplasia, diffusely located atypical cells (VP) |
| 5491 | 54.6 | PIN3 | PIN4 | PIN3 | Areas of hyperplasia (AP), apoptosis (VP) |
| 5584 | 54.6 | PIN2 | PIN4 | PIN4 | Hypertrophy/hyperplasia, few atypical cells (AP) |
| 5580 | 54.9 | PIN3 | PIN4 | PIN4 | Intraglandular focal necrosis (DLP) |
| 5581 | 54.9 | PIN4 | PIN4 | ||
Abbreviations: RS, regular structures as seen in the normal mouse prostate; PIN, prostatic intraepithelial neoplasm PIN 1 and PIN2, low grade (LG) PINs; PIN3 and PIN4, high grade (HG) PINs; Early cancer, microscopic cancer; Adca, adenocarcinoma. Lesion classifications were as described (28-30)