Table 2.

MSI Tumors Have Low Expression of RECQL and RECQL5.

Gene Expression	MSS	MSI	Total Cases	Percent MSI	Group Mean	SD
RECQL, T < N	12	6	18	33.3	0.50	0.30
RECQL, T > N	8	0	8	0	1.71	0.45
RECQL5, T < N	11	6	17	35.3	0.38	0.25
RECQL5, T > N	9	0	9	0	2.84	4.09
All cases	20	6	26	23.1

When either RECQL or RECQL5 expression was used to cluster cases into those that expressed the gene of interest less than the matched normal mucosa or those that expressed the gene more than the matched normal mucosa, we were able to identify two distinct subgroups (P < .05). MSI CRCs were observed only in cases where the expression of RECQL and RECQL5 were less in the CRC compared to the normal colon. These results suggest that MSI cases correlate with low RECQL and RECQL5 expression in the tumor compared to the matched normal mucosa. MSS, microsatellite stable (MSI negative).