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. 2013 Aug;15(8):925–938. doi: 10.1593/neo.13762

Figure 6.

Figure 6

Implications and relevance in human cancer. (A) Fibronectin content in tumors correlates with blood vessel numbers in the whole group including CT, Alb-cKO, and Mx-cKO mice (N = 4 CT, 3 Alb-cKO, and 3 Mx-cKO). Fibronectin content was determined by ELISA and corrected to protein content. (B) Fibronectin content in tumors determined by ELISA correlates with bioluminescence signal in the same groups as A. (C) Grading of staining intensity for breast and prostate cancer tissue arrays. (D) Fibronectin staining intensity is stronger in tumors that are ER negative (ER- = 42, ER+ = 39 samples). Kaplan-Meier survival curves for different fibronectin staining intensities in (E) breast cancer (N = 81) and (F) prostate cancer (N = 89). *P < .05, **P < .01, ***P < .001.