Table 2.
Effect | Level | Number of Patients | Cancer-Specific Survival | Time to Local Recurrence | Time to Metastasis Formation | ||||||
Global P | Events | HR with 95% CI | Global P | Events | HR with 95% CI | Global P | Events | HR with 95% CI | |||
PSA (ng/ml) | ≤4 | 18 | .168 | 0 | (Ref.) | .196 | 3 | (Ref.) | .335 | 1 | (Ref.) |
4–10 | 33 | 2 | 2 x 105 (0 to >1010) | 11 | 2.70 (0.75–9.75 | 4 | 2.74 (0.30–24.73) | ||||
>10 | 38 | 4 | 664 (0 to >1010) | 13 | 1.56 (0.67–3.61) | 6 | 1.81 (0.47–7.04) | ||||
89 | |||||||||||
T | 0 | 54 | .053 | 2 | (Ref.) | < .001 | 11 | (Ref.) | .001 | 3 | (Ref.) |
1 | 29 | 4 | 4.65 (0.84–25.6) | 16 | 4.66 (2.10–10.35) | 8 | 6.88 (1.81–26.14) | ||||
N | 0 | 83 | .001 | 4 | (Ref.) | < .001 | 24 | (Ref.) | .002 | 9 | (Ref.) |
1 | 5 | 2 | 9.86 (1.79–54.45) | 3 | 6.74 (1.98–22.90) | 2 | 8.03 (1.70–37.96) | ||||
Gleason score | 0–7a | 70 | .004 | 2 | (Ref.) | .004 | 17 | (Ref.) | .003 | 5 | (Ref.) |
>7a | 19 | 4 | 8.02 (1.47–43.84) | 10 | 2.96 (1.36–6.48) | 6 | 5.09 (1.55–16.67) | ||||
Resection | R0 | 71 | .007 | 3 | (Ref.) | .001 | 18 | (Ref.) | .015 | 7 | (Ref.) |
R1 | 18 | 3 | 7.27 (1.36–38.78) | 9 | 3.68 (1.64–8.26) | 4 | 4.29 (1.21–15.23) | ||||
Fibronectin score | 0 | 41 | .031 | 3 | (Ref.) | .086 | 11 | (Ref.) | .004 | 4 | (Ref.) |
1 | 36 | 0 | - | 13 | 1.98 (0.85–4.63) | 4 | 2.48 (0.56–10.99) | ||||
2 | 12 | 3 | 3390 (0 to >1010) | 3 | 1.63 (0.49–5.47) | 3 | 6.71 (1.72–26.08) | ||||
Fibronectin score | 0 + 1 | 77 | < .001 | 3 | (Ref.) | .420 | 24 | (Ref.) | .001 | 8 | (Ref.) |
2 | 12 | 3 | 12.83 (2.46–66.92) | 3 | 1.64 (0.49–5.49) | 3 | 7.00 (1.77–27.64) |
PSA indicates prostate-specific antigen; T, tumor size; N, nodal status; HR, hazard ratio; CI, confidence interval; Ref., reference. Significant P values are bolded.