Table 3.

Human Breast Cancer Cell Line Models [55,56].

Cell Line	Clinical Markers	Mutational Status*	Tumor Type	Tumor Classification
MDA-MB-231	TN-Claudin low	TP53	Adenocarcinoma†	Basal B
		KRAS‡
		BRAF§
		CDKN2A
MDA-MB-468	EGFR positive¶	PTEN	Adenocarcinoma†	Basal A
		TP53
		MADH4
		RB1
SKBR3	HER-2 positive#	(NA)**	Adenocarcinoma†	Luminal
T47D	ER/PR positive	PIK3CA	Invasive ductal carcinoma†	Luminal
		TP53
MCF-7	ER/PR positive	PIK3CA	Invasive ductal carcinoma†	Luminal
		CDKN2A

^*Cancer Genome Project, Sanger Institute (http://www.sanger.ac.uk/genetics/CGP/CellLines).

^†Isolated from metastatic pleural effusion.

^‡KRAS G13D mutation.

^§BRAF G464V mutation.

^¶EGFR overexpression (gene amplification).

^#HER-2 overexpression (gene amplification).

^**Not available.