Table 1.
Laminar Thickness (μm, Mean ± SD) of Normal Sprague-Dawley (n = 5) and P90 RCS Retinas (n = 5) as Determined by MRI and Histology
| Band | Pre-Gd | Post-Gd | Histology | Assignment |
|---|---|---|---|---|
| #1 | 65 ± 31 | 43 ± 16 | 31 ± 6 | ganglion cell layer + nerve fiber layer |
| #2 | 50 ± 3 | 47 ± 9 | 61 ± 4 | inner plexiform layer |
| #3 | 38 ± 6 | 38 ± 5 | 39 ± 6 | inner nuclear layer |
| #4 | 30 ± 7 | 33 ± 3 | 14 ± 3 | outer plexiform layer |
| #5 | 24 ± 1 | 28 ± 10 | 53 ± 8 | outer nuclear layer |
| #6 | 28 ± 3 | 30 ± 5 | 53 ± 8 | inner + outer segment |
| #7 | 44 ± 10a | 63 ± 13a | 18 ± 3 | choroidal vascular layer |
| Total | 275 ± 30b | 279 ± 30b | 252 ± 5 |
a
P < 0.05. The choroidal vascular layer post-Gd-DTPA was slightly thicker than pre-Gd-DTPA, likely due to the increased PVE associated with the marked increase in signal intensity. Both MRI determinations of choroidal vascular layer were statistically different from histological thickness.
b
Determined from the width of the entire retina including the choroid (not from summing up all the band thicknesses).