In silico effect of ABA administration on miRNA-146b expression. The model represents the interaction between DSS, ABA, miRNA-146, NCOA4, PPARγ, IL-10 and IFN-γ in SBML format (A). A COPASI scan task shows a down-regulation of miR-146b when ABA is administered to the system, resulting in increased concentrations of NCOA4, which, in turn, activates PPARγ and therefore favors IL-10 production and decreases IFN-γ levels (B). However, when PPARγ is deleted from the system, IL-10 production is drastically decreased. As a result, IFN-γ predominates due to DSS activation, and NCOA4 is unable to up-regulate PPARγ (C).