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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Nat Med. 2010 Apr;16(4):400–402. doi: 10.1038/nm0410-400

Figure 2.

Figure 2

Mechanisms for intracellular diacylglycerol (DAG) accumulation in muscle and liver. DAGs accumulate in skeletal muscle and liver when the rate of fatty acid delivery to these tissues exceeds the rates of intracellular fat oxidation and/or conversion to neutral lipid. The four main causes of net DAG accumulation are excess caloric intake, defects in adipocyte metabolism (which would include lipid storage and lipolysis), defects in mitochondrial fatty acid oxidation and gene variation in apolipoprotein C3, leading to inhibition of lipoprotein lipase activity. TCA, tricarboxylic acid.