Figure 2. Behavioral data - Experiment 1.
All mice received continuous training on the DNMTP task from 3 to 7 months of age. (a) During the final 5 days of DNMTP testing APP/PSEN1 mice (solid shapes) made more correct responses than wild-type mice (open shapes; P<.01). At 8 months of age mice were trained on a hidden-platform version of the water maze followed 24 hours later by a 60-s no-platform probe trial. (b) Although the pattern of swim-time in each quadrant varied among groups, all groups showed a significant preference for the target quadrant over the mean time spent in non-target quadrants during the probe trial (Ps<.05). (c) High EC-treated mice were less accurate than control-fed animals, with less time spent within 20 cm of the platform (P<.05). + P <.05 APP/PSEN1 mice different from wild-type mice and * P <0.05 vitamin-supplemented group different from control-treated mice.