Table 2.

Pharmacokinetic parameters of CsA control (alone) and coadministered with Lepidium sativum (mean ± SEM, n = 5).

Parameters	CsA alone (mean ± SEM)	With garden cress (mean ± SEM)
a C max (ng/mL)	999.76 ± 260.54	984.04 ± 79.42
b T max (hr)	1.13 ± 0.11	1.75 ± 0.13**
cAUC0–24 (ng·hr/mL)	2790.81 ± 541.71	3965.47 ± 609.20
dAUC0–∞ (ng·hr/mL)	2795.67 ± 542.28	3974.74 ± 606.11
eKel (hr−1)	0.44 ± 0.02	0.37 ± 0.03*
f T 1/2 (hr)	1.59 ± 0.08	1.96 ± 0.18*
gCL (L/Kg)	12.13 ± 2.04	8.67 ± 1.98
hMRT (hr)	2.92 ± 0.13	3.49 ± 0.39

*Significant difference from CsA alone group with t-test, *P ≤ 0.05, **P ≤ 0.01. ^amaximum blood concentration, ^btime of peak concentration, ^carea under the concentration time profile curve until last observation, ^darea under the concentration time profile curve from time 0 to infinity, ^eelimination rate constant, ^fhalf-life, ^gtotalclearance, and ^hmean residence time (MRT).