Table 1. Clinicopathologic features and CagA expression in localized gastric MALT lymphoma patients who received H. pylori eradication therapy as a front-line treatment.
| Clinicopathologic characteristics |
CagA expression |
Pa | |
|---|---|---|---|
| Negative (n=33) | Positive (n=31) | ||
| Age (median, range, years) | 56 (18–75) | 58 (30–86) | 0.246b |
| Sex, male/female | 13/20 | 9/22 | 0.438c |
| Endoscopic features, n (%) | 0.247d | ||
| Gastritis-like or multiple erosion on infiltrative mucosa | 11 (33.3%) | 13 (41.9%) | |
| Ulceration or ulcerated mass | 14 (42.4%) | 15 (48.4%) | |
| Erosions on giant nodular folds | 7 (21.2%) | 2 (6.5%) | |
| Mixed | 1 (3.0%) | 1 (3.2%) | |
| Location of tumor (s), n (%) | 0.089d | ||
| Proximale | 10 (30.3%) | 8 (25.8%) | |
| Distalf | 18 (54.5%) | 22 (71.0%) | |
| ⩾2 components | 5 (15.2%) | 1 (3.2%) | |
| Depth of gastric wall involvement, n (%)g | 0.010c | ||
| Submucosa or above | 17/31 (54.8%) | 24/28 (85.7%) | |
| Muscularis propria or beyond | 14/31 (45.2%) | 4/28 (14.3%) | |
| H. pylori-dependent status | <0.001c | ||
| H. pylori-dependent | 12 (36.4%) | 26 (83.9%) | |
| H. pylori-independent | 21 (63.6%) | 5 (16.1%) | |
Abbreviations: MALT, mucosa-associated lymphoid tissue.
a
P: comparison of discrete variables between CagA expression-positive and CagA expression-negative.
b
P-values (two-sided) were calculated using the Student's t-test.
c
P-values (two-sided) were calculated using χ2 test or Fisher's exact test.
d
P-values (two-sided) were calculated using one-way analysis of variance.
e
Proximal: Middle body, upper body, fundus or cardia.
f
Distal: Antrum, angle or lower body.
g
Gastric wall involvement was evaluated by endoscopic ultrasonography in 59 patients.