Figure 4.

LBP treatment reduced oxidative stress induced by NASH development. Expressional changes of (a) MDA formation, (b) nitrotyrosine formation, (c) catalase (CAT) mRNA, (d) glutathione peroxidase (GPx) mRNA and (e) CYP2E1 protein indicate an increased oxidative stress in the liver of high-fat diet-fed rats, which is attenuated by LBP treatment. Data from each group were expressed as means±s.e.m. (n=8). Statistical comparison between groups was done using the Kruskal–Wallis test followed by Dunn's post hoc test to detect differences between all groups. A P-value <0.05 was considered to be statistically significant with different letter labels. C, control; L, vehicle-LBP; N, NASH; N+L, NASH+LBP.