Figure 6.

LBP administration reduced hepatic apoptosis in NASH rats through the intrinsic and extrinsic pathways. (a) TUNEL results show that an increased TdT staining signal intensity in high-fat diet-fed rat livers. The apoptosis trend is attenuated by LBP treatment. Western blot results of key members in the (b) intrinsic apoptotic pathway and (c) extrinsic apoptotic pathway indicate that the anti-apoptotic effects of LBP are through both the pathways. Data from each group were expressed as means±s.e.m. (n=4–5). Statistical comparison between groups was done using the Kruskal–Wallis test followed by Dunn's post hoc test to detect differences between all groups. A P-value <0.05 was considered to be statistically significant with different letter labels. C, control; L, vehicle-LBP; N, NASH; N+L, NASH+LBP. Bar: 20 μm.