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. 2013 Jul 22;3(7):e81. doi: 10.1038/nutd.2013.22

Figure 7.

Figure 7

LBP treatment ameliorated NASH-induced hepatic injury through the kinase- and transcription factor-related pathways. Western blot results of the (a) PI3K/Akt/FoxO1, (b) LKB1/AMPK, (c) MEK/ERK and JNK/c-Jun pathways show the involvements of these pathways in NASH development and LBP amelioration. (d) The results of IκBα and electrophoretic mobility shift assay results of NF-κB/AP-1 in different groups of rats show that the NASH development is accompanied by the activation of NF-κB and AP-1. Treatment with LBP reduces such induction. Data from each group were expressed as means±s.e.m. (n=4–5). Statistical comparison between groups was done using the Kruskal–Wallis test followed by Dunn's post hoc test to detect differences between all groups. A P-value <0.05 was considered to be statistically significant with different letter labels. C, control; L, vehicle-LBP; N, NASH; N+L, NASH+LBP.