Fig. 3.—

Large and small UIR genes are transcriptionally promiscuous. Histogram of genome-wide gene expression samples (42 experiments across five species, 132 samples in total) showing significantly different expression for orthologs with conserved lower (L), mid (M), and upper (U) UIR quintiles, against matched control groups with variable size across species (LNC, low not conserved with small mean size across orthologous genes; UNC, upper not conserved with high mean size). Significance is measured for mean expression (against all shared orthologs), and for the number of genes up- or downregulated at an absolute log 2 ratio of 0.5 (see Materials and Methods).