Table 1.

Comparison of Drug Target Identity with Respect to Subcellular Localization at Both the DNA and the Protein Level

Group	Subcellular Localization	Mean Identity (%)	Nucleus	Cytoplasm	Membrane	Organelle	Extracellular
hum2mac	Nucleus	93.83	—
	Cytoplasm	91.89	0.0457	—
	Membrane	91.40	0.0123	0.2474	—
	Organelle	91.64	0.0057	0.0910	0.4642	—
	Extracellular	91.87	0.0003	0.0008	0.0105	0.0687	—
	Unknown	90.55	0.0050	0.0612	0.1988	0.4877	0.4877
hum2mouse	Nucleus	89.73	—
	Cytoplasm	88.02	0.0482	—
	Membrane	83.36	5.58E-06	0.0001	—
	Organelle	85.55	2.79E-06	0.0002	0.8756	—
	Extracellular	75.24	2.20E-16	2.20E-16	3.76E-12	2.38E-15	—
	Unknown	85.54	0.0046	0.1602	0.3405	0.2249	8.30E-10
hum2rat	Nucleus	86.73	—
	Cytoplasm	85.54	0.1116	—
	Membrane	80.83	4.94E-05	0.0002	—
	Organelle	82.79	2.38E-04	0.0024	0.5592	—
	Extracellular	74.07	2.15E-14	2.20E-16	2.62E-09	3.46E-12	—
	Unknown	81.61	0.0090	0.0906	0.6320	0.8258	2.60E-06

Note.—Pairwise P values among the subcellular categories are shown. P values were calculated by using the one-sided Wilcoxon rank-sum test.