Table 1.
Tumor cells | L858R | E746-A750 del | EGFR | Vector |
---|---|---|---|---|
Plateau level at 60 minutes1 | 3.12 ± 0.304 | 1.57 ± 0.17 | 1.47 ± 0.001 | 1.47 ± 0.001 |
Washout at 60 minutes2 | 1.78 ± 0.147* | 1.10 ± 0.16 | 1.17 ± 0.001 | 1.17 ± 0.001 |
Washout at 21 minutes | 1.09 ± 0.124* | 1.16 ± 0.20 | 0.55 ± 0.000* | 0.55 ± 0.000* |
1Volume of distribution at equilibrium expressed as cell-to-medium accumulation ratio (average ± standard error). 2Coefficient B (slope) of the exponential washout = A × exp(−BX).