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. 2013 Mar 14;22(16):2287–2297. doi: 10.1089/scd.2012.0499

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Copyright 2013, Mary Ann Liebert, Inc.

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FIG. 3. — Role of CD13 in adipogenesis. (A) mRNA expression levels of CD13 were significantly higher in Ob- than in Co-hA-MSCs at day 0 (P=0.05), day 2 (P=0.05), and day 4 (P=0.05) when cultured with the adipogenic medium. CD13 mRNA expression was switched-off in Ob-hA-MSCs after CD13 silencing with shRNA. (B) At day 4 of adipogenic induction, PPARγ mRNA expression levels that were significantly higher in Ob-hA-MSCs than in Co-hA-MSCs (P=0.02), decreased to the levels detected in Co-hA-MSCs after CD13 silencing (P=0.71), which indicates that CD13 enhances adipogenesis in hA-MSCs. n.s.: not statistically significant difference.