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Effect of curcumin on the mitochondrial permeability transition pore-openining from rats exposed to K2Cr2O7. (a) Mitochondrial swelling, (b) mitochondrial membrane potential dissipation, and (c) mitochondrial Ca2+ retention. Tracings are representative of three different experiments. Carbonyl cyanide m-chlorophenylhydrazone (CCCP) was added in control and curcumin groups to induce loss of membrane potential and Ca2+ release. CUR: curcumin; CsA: cyclosporine A.
