Table 1.
Effect of curcumin pretreatment on K2Cr2O7-induced alterations in mitochondrial oxygen consumption using succinate as substrate.
| Control | CUR | K2Cr2O7 (24 h) | CUR-K2Cr2O7 (24 h) | K2Cr2O7 (48 h) | CUR-K2Cr2O7 (48 h) | |
|---|---|---|---|---|---|---|
| Succinate | ||||||
| State 3 (ngAtO/min/mg protein) | 243 ± 24 | 192 ± 9 | 169 ± 24 | 170 ± 36 | 156 ± 13a | 180 ± 27 |
| State 4 (ngAtO/min/mg protein) | 59 ± 5 | 48 ± 2 | 51 ± 7 | 40 ± 10 | 49 ± 4 | 51 ± 5 |
| RCI | 4.1 ± 0.3 | 4.0 ± 0.2 | 3.5 ± 0.1 | 4.3 ± 0.2 | 3.2 ± 0.3 | 3.5 ± 0.4 |
| Uncoupled respiration (ngAtO/min/mg protein) | 396 ± 34 | 363 ± 21 | 284 ± 39 | 269 ± 63 | 245 ± 34a | 269 ± 18 |
| ADP/O | 1.3 ± 0.1 | 1.6 ± 0.1 | 1.6 ± 0.1 | 1.6 ± 0.2 | 1.4 ± 0.2 | 1.4 ± 0.1 |
Values are mean ± SEM, n = 4-5. CUR: curcumin; RCI: respiratory control index. a P < 0.05 versus control.