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GCV induces apoptosis in senescent (SEN) cells through mtDNA fragmentation. (a) HCA2 and HCA2-3MR were rendered senescent using x-ray irradiation as in Figure 3 and were treated with 0.1 μg/ml of tritiated GCV. mtDNA was isolated and radioactivity measured. Incorporated GCV molecules per molecule of mtDNA is depicted. (b) mtDNA from control or irradiation-induced senescent cells treated or not with 10 μg/ml GCV were analyzed by agarose gel electrophoresis
