Figure 2.

LPV decreases the proliferation and clonogenicity of CSCs. Dose-response curves for LPV-induced inhibition of cell proliferation for CSCs (open circle) or the total tumor population (closed circle) from an adenocarcinoma (a), or an intestinal tumor (b). Grey zones represent the plasma concentrations of LPV in treated patients, as reported in the literature. The results represent the mean±S.E.M. of three experiments carried out in duplicate. Error bars were omitted when the S.E.M. was smaller than the size of the symbol. IC₅₀s were calculated from the curves. (c) LPV reduces CSC clonogenicity. After growing 170 cells on methylcellulose for 3 weeks, the percentage of colonies obtained from Oct-4-expressing cells was calculated. Mean±S.E.M. was representative of three independent experiments (***P<0.001)