Figure 5.

Abexinostat modulates expression of genes involved in DNA repair. (a) Gene set enrichment analysis (GSEA) of CD41⁺ cells treated with 100 nM of abexinostat reveals that DNA repair, DNA double-strand break (DSB), DNA recombination and response to DNA damage were the most prominent signatures of abexinostat-treated cells. (b) RAD51 protein level by immunoblot analysis. Day 7 CD41⁺-sorted MK were cultured for 48 h with TPO with or without increasing the dose of abexinostat. HSC70 was used as loading control