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Dynamic binding of H1 to chromatin. According to Brown et al.33, the binding of H1 to chromatin is a multistep process initiated by a charge-based, low-affinity interaction of the C-terminal domain with the linker DNA, allowing the globular domain to ‘scan’ the nucleosome core for optimum placement. Proper placement of the globular domain induces conformational changes in the H1 flanks and leads to structural changes in chromatin.
