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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Nat Struct Mol Biol. 2006 Apr;13(4):305–310. doi: 10.1038/nsmb1077

Figure 4.

Figure 4

Determinants of H1-nucleosome interactions. From left: the unique structural features of H1 are the major factor promoting its binding to chromatin (1); regulatory cofactors promote the binding of specific H1 variants to unique nucleosomes (2); post-translational modification of either H1 or chromatin generally reduces the binding of H1 to chromatin (3); site-specific transcription factors (TF) and similar regulatory factors compete with and reduce the binding of H1 to specific chromatin sites (4); non–sequence-specific nucleosome-binding proteins such as HMGs act as global competitors that weaken the interaction of H1 with nucleosomes throughout the entire chromatin (5).