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A/Ncr mice were intranasally infected with 5 plaque-forming units of ectromelia virus. (A) Mice were monitored for mortality for 42 days. Viral DNA copies were measured from blood on days 5, 6, 7 and 8 post-infection. (B) Mortality correlated with increased levels of asparate aminotransferase (AST) and alanine aminotransferase (ALT) that indicated liver damage.
