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. 2013 Sep 6;10(86):20130487. doi: 10.1098/rsif.2013.0487

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© 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 8. — Comparison of calcium transients observed in cultured normal human urothelial cells and generated by the theoretical model in different extracellular calcium concentrations. (a) Application of ATP with [Ca²⁺]_EX = 0.09 mM triggers transients that are composed of an initial upward fluctuation in cytosolic calcium concentration followed by a rapid return to baseline. The first three panels show examples of experimentally recorded transients. The right most panel shows a transient generated by the model. The transient is very similar in nature to the experimental data, with an initial peak followed by a rapid return to baseline. Parameters have been set to the default values in the electronic supplementary material, table S1, with the exception that a_ionic, and have been scaled by factors of 0.2, 0.4 and 0.2, respectively. (b) With [Ca²⁺]_EX = 2 mM, the transients that are composed of an initial peak followed by an extended plateau. The first three panels show examples of experimentally recorded transients. The right most panel shows the theoretical result, using the same parameter set that produced the transient in row A. The model successfully captures the transition to a peak-plateau response observed in the experimental data.

Inline graphic — Comparison of calcium transients observed in cultured normal human urothelial cells and generated by the theoretical model in different extracellular calcium concentrations. (a) Application of ATP with [Ca²⁺]_EX = 0.09 mM triggers transients that are composed of an initial upward fluctuation in cytosolic calcium concentration followed by a rapid return to baseline. The first three panels show examples of experimentally recorded transients. The right most panel shows a transient generated by the model. The transient is very similar in nature to the experimental data, with an initial peak followed by a rapid return to baseline. Parameters have been set to the default values in the electronic supplementary material, table S1, with the exception that a_ionic, and have been scaled by factors of 0.2, 0.4 and 0.2, respectively. (b) With [Ca²⁺]_EX = 2 mM, the transients that are composed of an initial peak followed by an extended plateau. The first three panels show examples of experimentally recorded transients. The right most panel shows the theoretical result, using the same parameter set that produced the transient in row A. The model successfully captures the transition to a peak-plateau response observed in the experimental data.