Figure 21.

Electron micrograph of similar region after 1.7 mg Taxol administration showing degenerative changes in podocytes (arrow). Glomerular lumen is dilated and contains cells (white arrow). The cytoplasm of one cell showed large vacuole (v) compressing the nucleus, podocytes. Similar part of mice PCT showing destruction of apical microvillus (white arrow) the nucleus (N) showed irregular shape and abnormal distribution of peripheral chromatin (star) and nucleolus (NU). Basal enfolding enclosed abnormal dark stained mitochondria (M) surrounded by light spaces. The basement membrane (BM) is irregular and thickened.