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. 2013 Aug;183(2):344–351. doi: 10.1016/j.ajpath.2013.04.025

Figure 2.

Figure 2

Acetylated and hyperphosphorylated tau pathological characteristics in sporadic and hereditary tauopathies. A–P: Representative images of AC-K280 staining and B-R display PHF-1 staining. Sections from the amygdala in AGD show prominent AC-K280–reactive grains (arrowheads; A and C) and neurofibrillary tangles (NFTs; asterisk; A) and ballooned neurons (asterisk; C) similar to PHF-1 (B and D). AC-K280 reactivity in the cornu ammonis (CA-1) region of the hippocampus in TPSD is seen mostly in intracellular tangles (arrow; E), with less prominent staining of threads and extracellular ghost tangles labeled by PHF-1 (F). CA-1 region of the hippocampus of a PSEN1 case (p.S170P) displays typical AD pathological characteristics, with AC-K280 mainly in tangles (asterisk) and neuritic plaques (arrow; G) and less prominent in diffuse threads than PHF-1 (H). Superior temporal cortex (STC) of FTDP-17 cases (p.P301L and IVS10 + 16) have ACK280-reactive neuronal inclusions (I and M) and less prominent threads than PHF-1 (J and N) in gray matter (GM) and a similar burden of glial tau pathological features in white matter (WM; arrow; K and L). Nonneurodegnerative disease control superior temporal cortex showing an absence of AC-K280 (Q) and PHF-1 reactivity (R). Scale bar = 100 μm (R).