Figure 5.

Treatment of Thy1 nephritis with TH1177 reduces glomerular cell proliferation, macrophage infiltration, and ERK activation. Representative images of kidneys show they were immunostained for Ki-67 (A–C), ED1 (D–F), and pERK (G–I). Examples of positively stained cells are marked with arrows. J: TH1177 treatment of Thy1 nephritis caused a significant reduction in Ki-67-positive nuclei per glomerulus. ^∗∗P = 0.007 versus placebo. K: There were significantly fewer ED1-positive cells in the TH1177-treated group than the placebo group. ^∗∗P = 0.007. L: The reduction in glomerular cell proliferation was paralleled by a 52% reduction in glomerular cells stained positively for phosphorylated ERK. ^∗∗P < 0.005 versus placebo.