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. 2013 Aug;183(2):422–430. doi: 10.1016/j.ajpath.2013.05.006

Figure 3.

Figure 3

DMA suppresses recruitment of inflammatory cells to the placental labyrinth in LPS-treated mice. Placentas were harvested rapidly and fixed in 10% buffered formalin from three different groups of animals: sham control mice treated with PBS only (n = 4) (A), mice treated with LPS and PBS (n = 4) (B), and mice treated with LPS and 1.56 mg/kg DMA (n = 4) (C). For histologic analysis, fixed tissues were dehydrated and paraffin embedded, sectioned at 4 μm, and stained with H&E. Inflammatory cell infiltrates were graded as described. Numbers of polymorphonuclear neutrophils in sections of mouse placental labyrinth tissue from mice treated with LPS were compared with those in sham controls treated with PBS only (P < 0.01) and with those from mice rescued from LPS-induced PTB with 1.56 mg/kg DMA (P < 0.01) (D). Insets: Higher magnification (×600), showing increased number of inflammatory cells in LPS-stimulated tissue (B compared to A) and relatively decreased number of inflammatory cells resulting from treatment with DMA (C compared to B).