Figure 4.

DMA suppresses expression of placental inflammatory signaling molecules in LPS-treated mice. Placental tissue lysates from LPS-induced mice (n = 4) and LPS-treated mice rescued from PTB with 1.56 mg/kg DMA (n = 4) were subjected to gel electrophoresis and immunoblotting. Band densities from control mice induced to PTB were normalized to 1.0 and compared with band densities from rescued mice after probing Western blots with antibodies directed against IL-1β (P < 0.01), TNF α (P < 0.001), and IL-6 (P < 0.05) (A); MMP-8 (P < 0.05) (B), and IL-10 (P < 0.001) (C). Glyceraldehyde-3-phosphate dehydrogenase was used for gel loading controls (lower bands). ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001.