Table 1.

DMA Prevents LPS-Triggered PTB and Spontaneous Abortions in a Dose-Dependent Fashion

Group	Control	DMA treatment, mg/kg					Sham
		0.2	0.39	0.78	1.56	3.1
Received 50 mg/kg LPS	Yes	Yes	Yes	Yes	Yes	Yes	No
Number of mice	9	7	8	10	6	8	4
Number of mice that delivered	8	5	3∗	2†	0†	0‡	0
Number of pups	69	47	46	73	47	52	28
Number of pups spontaneously aborted	30	12†	5§	4§	0§	0§	0

Mice were treated with LPS followed by varying does of DMA, as indicated. Sham mice were injected with PBS in lieu of LPS. The proportion of LPS-induced mice delivering was decreased significantly at the four highest doses of DMA. The proportion of pups prematurely delivered and hence spontaneously aborted was reduced significantly at all five doses of DMA tested.

^∗P < 0.05.

^†P < 0.01.

^‡P < 0.001.

^§P < 0.0001.