Table 2.
ORs with corresponding 95% CIs and P values for interaction for each outcome in outborn and inborn subgroups after adjustment for center and severity of encephalopathy
| Delivery site | Rate (%)
|
Adjusted OR (95% CI) |
P value (interaction)
|
|||
|---|---|---|---|---|---|---|
| Hypothermia | Control | Unadjusted | Center, HIE severity adjusted | |||
| Death/moderate or severe disability, % | Outborn | 50 | 68.2 | 0.81 (0.29–2.24) | 0.91 | 0.87 |
| Inborn | 38.9 | 58.3 | 0.91 (0.33–2.45) | |||
| Death, % | Outborn | 27.1 | 43.2 | 0.85 (0.27–2.74) | 0.88 | 0.93 |
| Inborn | 20.4 | 31.7 | 0.80 (0.28–2.31) | |||
| Bayley MDI score ≥ 85, % | Outborn | 37.5 | 28.9 | 0.81 (0.29–2.28) | 0.31 | 0.37 |
| Inborn | 38.9 | 19.7 | 0.44 (0.15–1.25) | |||
| Bayley MDI score 70–84, % | Outborn | 18.5 | 21.3 | 1.21 (0.29–4.96) | 0.94 | 0.93 |
| Inborn | 14.6 | 0 | 0 | |||
| Bayley MDI score <70, % | Outborn | 47.9 | 71.1 | 1.1 (0.41–3.02) | 0.63 | 0.57 |
| Inborn | 42.6 | 59.1 | 0.77 (0.29–2.02) | |||
| Bayley PDI ≥ 85, % | Outborn | 35.4 | 24.4 | 1.95 (0.67–5.65) | 0.76 | 0.92 |
| Inborn | 53.7 | 37.7 | 1.82 (0.64–5.14) | |||
| Bayley PDI score 70–84, % | Outborn | 12.5 | 4.4 | 0.23 (0.03–1.56) | 0.15 | 0.21 |
| Inborn | 3.7 | 6.6 | 1.15 (0.17–7.90) | |||
| Bayley PDI score < 70, % | Outborn | 52.1 | 71.1 | 0.83 (0.30–2.31) | 0.67 | 0.57 |
| Inborn | 42.6 | 55.7 | 0.57 (0.21–1.53) | |||
| Cerebral palsy, % | Outborn | 31.4 | 45.8 | 0.21 (0.04–0.96) | 0.60 | 0.40 |
| Inborn | 9.5 | 22.5 | 0.48 (0.13–1.83) | |||
| Blindness, % | Outborn | 5.9 | 20.8 | 1.44 (0.17–12.4) | 0.38 | 0.46 |
| Inborn | 7.3 | 10.2 | 0.55 (0.09–3.36) | |||
| Severe hearing impairment, % | Outborn | 2.9 | 12.5 | 0.12 (0.01–1.03) | 0.10 | 0.06 |
| Inborn | 4.8 | 2.5 | 1.75 (0.25–12.4) | |||
| Organ dysfunction | ||||||
| Pulmonary | Outborn | 12.5 | 20 | 1.26 (0.37–4.25) | 0.41 | 0.41 |
| Inborn | 24.1 | 22.9 | 0.66 (0.22–1.96) | |||
| Cardiac | Outborn | 57.5 | 43.2 | 0.50 (0.22–1.11) | 0.41 | 0.38 |
| Inborn | 39.2 | 37.7 | 0.80 (0.36–1.75) | |||
| Renal | Outborn | 16.7 | 28.9 | 2.11 (0.58–7.71) | 0.16 | 0.16 |
| Inborn | 22.6 | 18 | 0.69 (0.21–2.22) | |||
| Hematologic | Outborn | 20.8 | 17.8 | 0.62 (0.16–2.43) | 0.40 | 0.45 |
| Inborn | 15.1 | 6.6 | 0.30 (0.06–1.41) | |||
| GI, metabolic, or infectious | Outborn | 20.8 | 8.9 | 1.16 (0.27–4.96) | 0.18 | 0.06 |
| Inborn | 18.9 | 19.7 | 7.32 (1.40–38.2) | |||
CI, confidence interval; GI, gastrointestinal; HIE, hypoxic-ischemic encephalopathy; MDI, Mental Developmental Index; OR, odds ratio; PDI, Psychomotor Developmental Index.