Table 5.

Advanced stage breast cancer rates per 1000 mammograms by comorbidity status and time to previous mammogram ^c (N=3316)

	Overall		4–18 Months		19–30 months		31–42 months		>42 months/first screening d
	Rate (95% CI)	p	Rate (95% CI)	p	Rate (95% CI)	p	Rate (95% CI)	p	Rate (95% CI)	p
All	0.8 (0.7,0.9)	--	0.7 (0.6,0.8)	--	0.9 (0.7,1.2)	--	1.6 (1.1,2.4)	--	1.7 (1.2,2.4)	--
No comorbidities	0.5 (0.3,0.8)	Ref	0.3 (0.2, 0.6)	Ref	0.4 (0.1, 1.5)	Ref	2.2 (0.8, 5.9)	Ref	1.3 (0.4, 3.9)	Ref
Stable a comorbidities	0.8 (0.7,0.9)	0.065	0.7 (0.6, 0.8)	.03	0.9 (0.6, 1.3)	0.803	1.0 (0.5, 1.9)	0.024	1.5 (0.9, 2.5)	0.422
Unstable b comorbidities	1.1(0.9,1.3)	0.002	0.9 (0.7, 1.2)	0.004	1.0 (0.6, 1.6)	0.975	2.7 (1.6, 4.7)	0.242	2.2 (1.3, 3.9)	0.562

Results adjusted for covariates (age, race/ethnicity/BCSC registry)

^aStable comorbidities are defined as age-related conditions with no influence on predicted 5 year mortality. Examples include arthritis, osteoporosis, depression, diabetes, thyroid disorders, stable coronary artery disease, and peptic ulcer disease (Appendix 1).

^bUnstable comorbidities are defined as life threatening or difficult to control with less than 5 year predicted mortality. Examples include severe heart failure, end-stage pulmonary disease, end-stage liver disease, renal disease, and diabetes with complications (Appendix 1).

^cMammography use was categorized according to type of examination and time between mammography examination time interval since the prior mammography examination. Time to prior mammogram was calculated using last mammogram before cancer diagnosis for women with a cancer diagnosis and a randomly selected mammogram for women with no cancer diagnosis.

^d>42 months or first screen is defined as a screening mammogram with no prior mammogram within 42 months.