Table 4.
Best response in patients with anaplastic large-cell lymphoma, inflammatory myofibroblastic tumour, or non-small-cell lung cancer, by accession number
Dose level (mg/m2 per dose) | Part | Measurable or evaluable disease | Best response | Cycle maximum response observed | Total cycles | |
---|---|---|---|---|---|---|
Anaplastic large-cell lymphoma (n=9)
| ||||||
Patient 37 | 165 | A2 | Measurable | SD | .. | >30* |
Patient 38 | 165 | A2 | Measurable | CR | 2 | 9† |
Patient 39 | 165 | A2 | Measurable | CR | 1 | >28* |
Patient 41 | 165 | A2 | Measurable | CR | 5 | 6† |
Patient 42 | 165 | A2 | Measurable | CR | 3 | >23* |
Patient 43 | 165 | A2 | Measurable | CR | 1 | 4† |
Patient 57 | 280 | A2 | Measurable | CR | 2 | 12 |
Patient 62 | 280 | A2 | Evaluable | CR | 2 | >16* |
Patient 78 | 280 | A2 | Measurable | PR | 1 | >7* |
| ||||||
Inflammatory myofibroblastic tumour (n=7)
| ||||||
Patient 4 | 100 | A1 | Measurable | SD | .. | 24 |
Patient 45 | 165 | A2 | Measurable | PR | 1 | >20* |
Patient 48 | 280 | A1 | Measurable | PR | 5 | >19* |
Patient 69 | 280 | A2 | Measurable | SD | .. | >14* |
Patient 73 | 280 | A2 | Evaluable | SD | .. | 5 |
Patient 74 | 280 | A2 | Measurable | SD | .. | 3 |
Patient 75 | 280 | A2 | Measurable | PR | 3 | >11* |
| ||||||
Non-small-cell lung cancer (n=2)
| ||||||
Patient 30 | 165 | A2 | Measurable | SD | .. | 5 |
Patient 36 | 165 | A2 | Measurable | PR | 3 | 16 |
SD=stable disease. CR=complete response. PR=partial response.
Patient still on protocol therapy.
Patient off treatment to receive bone marrow transplant.