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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Future Med Chem. 2012 Feb;4(2):151–162. doi: 10.4155/fmc.11.183

Figure 2. Adenoviral transduction of butyrylcholinesterase-based cocaine hydrolase.

Figure 2

Enzyme transduction versus vector dose. Rat plasma samples were collected 5 days after injection of Ad5-cytomegalovirus-cocaine esterase or Ad5-cytomegalovirus-AME359, Vector doses are shown as multiples of the ‘standard’, which was 2.2 × 109 plaque-forming units delivered through the tail vein. Data points represent mean cocaine hydrolase activity (‘cocaine esterase activity’) in duplicate assays from each individual rat, graphed on a logarithmic scale. Note the million-fold range of recorded activities [21].