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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Future Med Chem. 2012 Feb;4(2):151–162. doi: 10.4155/fmc.11.183

Figure 5. In vivo transduction of multiple cocaine hydrolases by different viral vectors.

Figure 5

Mice and rats were given type 5 E-1-deleted adenoviral vectors or 2/8-AAV vectors with cytomegalovirus promoters at respective doses of 1010 and 3 × 1010 viral particles, intravenously. Plasma cocaine hydrolase activities (shown) were examined at time of peak expression, approximately 5 days after treatment. Tested BChE variants were: Mutant-1 (A199S/F227A/S287G/A328W/Y332G); Mutant-2 (F227A/S287G/A328W/Y332G); Mutant-3 (A199S/S287G/A328/Y332G) = CocHl; Mutant-4 (A199S/F227A/S287G/A328W/Y332G/E441D = CocH3; and Mutant-5 (F227A/S287G/A328W/Y332M) = AME [L Geng, y gao, S Brimijoin, Unpublished Data] .