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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Adv Mater. 2011 Mar 10;23(12):H41–H56. doi: 10.1002/adma.201003963

Figure 1. Chemical modifications of HA.

Figure 1

(A) A hypothetical composite structure illustrating selected primary modifications discussed herein: adipic dihydrazide for use in further crosslinking via acrylamide or hydrazone linkages; butane-1,4-diol diglycidyl ether, a prototypical monolithic crosslinker for HA; tyramide for peroxidase crosslinking; dialdehyde obtained by periodate oxidation; methacrylate on primary 6-hydroxyl group; benzyl ester; glycidyl methacrylate; thiopropionyl hydrazide from DTPH modification; bromoacetate; an unmodified disaccharide unit for comparison. (B) A thioether crosslinked semi-synthetic ECM formed by crosslinking thiol-modified carboxymethyl HA (CMHA-S) with thiol-modified gelatin using the bifunctional crosslinker, PEGDA.