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Spindle checkpoint pathway. Mps1 phosphorylates Spc105 to recruit the Bub1/3 proteins. Once Bub1/3 are bound to phosphorylated Spc105, the Mad1/Mad2 complex is recruited to the kinetochore. The open form of Mad2 is converted to a closed form, and the closed Mad2 binds to Cdc20 and eventually forms a mitotic checkpoint complex (containing Bub3, Mad2, Mad3, and Cdc20) that inhibits the progression into anaphase.
