Table 3.
Particle size distribution of fluconazole multilamellar liposomes (phosphatidylcholine:cholesterol 1:0.8 M ratio) of different charges.
| Cumulative distribution percentile | Particle volume (μm) of liposomal formulations |
||
|---|---|---|---|
| Neutrala | Negatively-chargedb | Positively-chargedc | |
| 10.0% | 2.62 | 1.48 | 4.49 |
| 20.0% | 3.36 | 2.63 | 5.92 |
| 50.0% | 4.93 | 4.11 | 8.73 |
| 80.0% | 6.69 | 5.86 | 10.78 |
| 90.0% | 7.38 | 5.24 | 11.35 |
| Distribution modal sizes (μm) | 7.20 | 6.00 | 10.79 |
a
Phosphatidylcholine:cholesterol:α-tocopherol acetate (1:0.8:0.1) molar ratio.
b
Phosphatidylcholine:cholesterol:dicetyl phosphate:α-tocopherol acetate (1:0.8:0.1:0.1) molar ratio.
c
Phosphatidylcholine:cholesterol:stearylamine:α-tocopherol acetate (1:0.8:0.1:0.1) molar ratio.