Table 4.
Diffusional order of release of fluconazole from different liposomal formulations using the correlation coefficient parameter.
| Liposomal formulation composition (molar ratio) | Liposomal formulation charge | Kinetic analysis using correlation coefficient (r) according to |
||
|---|---|---|---|---|
| Zero order | First order | Diffusion | ||
| Phosphatidylcholine:cholesterol:α-tocopherol acetate (1:0.6:0.1) | Neutral | 0.9789 | 0.9925 | 0.9981 |
| Phosphatidylcholine:cholesterol:stearylamine:α-tocopherol acetate (1:0.6:0.1:0.1) | Positive | 0.9795 | 0.9949 | 0.9989 |
| Phosphatidylcholine:cholesterol:dicetyl phosphate:α-tocopherol acetate (1:0.6:0.1:0.1) | Negative | 0.9936 | 0.9962 | 0.9978 |
| Phosphatidylcholine:cholesterol:α-tocopherol acetate (1:0.8:0.1) | Neutral | 0.9783 | 0.9904 | 0.9943 |
| Phosphatidylcholine:cholesterol:stearylamine:α-tocopherol acetate (1:0.8:0.1:0.1) | Positive | 0.9895 | 0.9949 | 0.9952 |
| Phosphatidylcholine:cholesterol:dicetyl phosphate:α-tocopherol acetate (1:0.8:0.1:0.1) | Negative | 0.9815 | 0.9928 | 0.9933 |