Table 5.
Stability of multilamellar fluconazole liposomes (1:0.8) molar ratio of different charges stored at 4 °C and 25 °C.
| Time (days) | Fluconazole retained in multilamellar liposomes (% ±S.D.) |
|||||
|---|---|---|---|---|---|---|
| Stored at 25 °C |
Stored at 4 °C |
|||||
| Neutrala | Negatively-chargedb | Positively-chargedc | Neutrala | Negatively-chargedb | Positively-chargedc | |
| Zero | 100 ± 000 | 100 ± 000 | 100 ± 000 | 100 ± 000 | 100 ± 000 | 100 ± 000 |
| 15 | 85.439 ± 0.314 | 89.453 ± 0.521 | 92.652 ± 0.313 | 89.556 ± 0.244 | 93.386 ± 0.175 | 95.742 ± 0.426 |
| 30 | 79.986 ± 0.436 | 86.639 ± 0.421 | 89.864 ± 0.362 | 87.653 ± 0.177 | 92.476 ± 0.355 | 94.833 ± 0.217 |
| 60 | 73.974 ± 0.328 | 83.748 ± 0.352 | 88.649 ± 0.279 | 87.843 ± 0.466 | 88.638 ± 0.351 | 91.438 ± 0.531 |
| 90 | 72.785 ± 0.364 | 81.698 ± 0.522 | 84.548 ± 0.467 | 86.439 ± 0.288 | 87.721 ± 0.411 | 88.853 ± 0.253 |
a
Phosphatidylcholine:cholesterol:α-tocopherol acetate (1:0.8:0.1) molar ratio.
b
Phosphatidylcholine:cholesterol:dicetyl phosphate:α-tocopherol acetate (1:0.8:0.1:0.1) molar ratio.
c
Phosphatidylcholine:cholesterol:stearylamine:α-tocopherol acetate (1:0.8:0.1:0.1) molar ratio.