Table 6.

Retention of fluconazole in freeze-dried multilamellar liposomes as a function of cryoprotectants/lipid mass ratio.

g Cryoprotectant/g lipid	Fluconazole retained in liposomal formulations (% ±S.D.)
	Neutrala	Negatively-chargedb	Positively-chargedc
None	61.544 ± 0.212	62.221 ± 0.456	63.452 ± 0.218
1 g glucose/g lipid	64.254 ± 0.423	65.877 ± 0.327	66.454 ± 0.447
2 g glucose/g lipid	67.329 ± 0.531	68.965 ± 0.463	69.789 ± 0.376
3 g glucose/g lipid	81.705 ± 0.638	82.543 ± 0.237	82.844 ± 0.374
4 g glucose/g lipid	81.644 ± 0.538	82.237 ± 0.448	83.994 ± 0.472
1 g lactose/g lipid	70.784 ± 0.365	71.662 ± 0.463	72.735 ± 0.518
2 g lactose/g lipid	83.133 ± 0.432	83.244 ± 0.165	81.821 ± 0.341
3 g lactose/g lipid	85.174 ± 0.136	85.867 ± 0.581	86.249 ± 0.361
4 g lactose/g lipid	88.328 ± 0.462	88.655 ± 0.418	89.952 ± 0.419
1 g trehalose/g lipid	77.167 ± 0.376	77.871 ± 0.365	78.654 ± 0.356
2 g trehalose/g lipid	86.932 ± 0.368	87.429 ± 0.384	90.634 ± 0.163
3 g trehalose/g lipid	89.622 ± 0.451	90.633 ± 0.473	91.877 ± 0.278
4 g trehalose/g lipid	91.659 ± 0.428	92.741 ± 0.276	92.855 ± 0.481

^aPhosphatidylcholine:cholesterol:α-tocopherol (1:0.8:0.1) molar ratio.

^bPhosphatidylcholine:cholesterol:dicetyl phosphate:α-tocopherol (1:0.8:0.1:0.1) molar ratio.

^cPhosphatidylcholine:cholesterol:stearylamine:α-tocopherol (1:0.8:0.1:0.1) molar ratio.