Table 2.
The inhibitory effect of the tested compounds against the gram positive bacteria Staphyloccous aureus (SA), the gram negative bacteria Escherichia coli (EC), and the pathogenic fungi Candida albicans (CA) using 20 μl concentration of the tested compounds. The cytotoxic concentration (CD50) and the antiviral activity against HSV-1 of the tested compounds and the antiviral antibiotic aphidicolin.
| Compound⁎ | The tested organism |
% Reduction in number in plaques | Minimum Antiviral Conc. (mg/ml) | Cytotoxicity (CD50) mg/ml | ||
|---|---|---|---|---|---|---|
| S. aureus | E. coli | C. albicans | ||||
| 18 | S++ | R | S++ | 18 | 0.21 | 0.02 |
| 19 | S+ | R | S+ | 20 | 0.21 | 0.01 |
| 21 | S++ | R | S+ | 20 | 0.20 | 0.03 |
| 22 | R | R | R | – | – | – |
| 23 | S+ | R | R | 19 | 0.20 | 0.03 |
| 24 | R | R | R | – | – | – |
| 26 | R | R | R | – | – | – |
| 28 | S++ | R | S+ | – | – | – |
| 29 | S+ | R | R | – | – | – |
| 32 | R | R | R | – | – | – |
| Ampicillin | S++++ | S+++ | Not tested | – | – | – |
| Clotrimazole | Not tested | Not tested | S++++ | – | – | – |
| Aphidicolin | – | – | – | 100 | 0.005 | 0.20 |
R = resistant, S+ = weakly active, S++ = moderately active, S+++ = strongly active, S++++ = remarkably active.
⁎
Compounds not listed in the table are completely inactive.