Figure 3.

Inhibition of H-FABP mRNA expression in the heart as a novel mechanism for DOX-induced cardiotoxicity and for L-carnitine mediated protection against this effect. FFA: free fatty acid; CT: carnitine/acyl-carnitine translocase; FA-CoA: fatty acyl-CoA; CAT: carnitine acetyl transferase; FA-Carnitine: fatty acyl-carnitine; H-FABP: heart-type fatty acid binding protein; CPT I: outer carnitine palmitoyl transferase; CPT II: inner carnitine palmitoyl transferase; OCTN2: organic cation/carnitine transporter; (−) and (+) indicate inhibition and stimulation, respectively.

(Cited from Sayed-Ahmed et al. (2000b).)