Table 1.

Intestinal permeability of furosemide through non-everted and everted rat intestinal sacs in presence or absence of the P-gp inhibitor verapamil, Tween 80 or hydroxypropyl β-cyclodextrin (HPβCD). Value are presented as mean (STD).

Applied solution	Papp (cm/s) × 106
	Non-everted sac (M-to-S)	Everted sac (S-to-M)	Ratio (S-to-M)/(M-to-S)
Drug solution	0.636 (0.093)	3.54 (0.67)	5.6
Drug + verapamil	4.81 (2.2)	6.17 (1.75)	1.28⁎
Drug + Tween 80	3.8 (1.1)	4.12 (0.8)	1.08⁎
Drug + HPβCD	0.703 (0.12)	3.22 (0.48)	4.58

M-to-S, the mucosal to serosal transport.

S-to-M, the serosal to mucosal transport.

^⁎Significantly different than control (drug solution alone).