Table 2.

Distributionof APOE genotypes and alleles in the case-control association study

	Type I	Type I	P	Type I	Type I	P
	diabetes	diabetes	value	diabetes	diabetes	Value
	subjects	subjects		subjects	subjects
	with	without		with	without
	nephropathy	nephropathy		retinopathy	retinopathy
	(DN+)	(DN-)		(DR+)	(DR-)
	n (%)	n (%)		n (%)	n (%)
	m/f (%/%)	m/f (%/%)		m/f (%/%)	m/f (%/%)
	74 (100)	92(100)		76 (100)	96(100)
Total subjects	40/34	40/52		34/42	50/46
	(54.0/46.0)	(43.5/56.5)		(44.7/55.3)	(52.1/47.9)
		2(2.2)			1(1.0)
E2E2	0	0/2	NS	0	0/1	NS
		(0/3.8)			(0/2.2)
	48(64.9)	54(58.7)		45(59.2)	61(63.6)
E3E3	25/23	27/27	NS	21/24	33/28	NS
	(62.5/67.6)	(67.5/51.9)		(61.8/57.1)	(66.9/60.9)
					1(1.0)
E4E4	0	0	NS	0	0/1	NS
					(0/2.2)
	13(17.6)	20(21.7)		18(23.7)	16(16.7)
E2E3	8/5	5/15	NS	9/9	6/10	NS
	(20.0/14.7)	(12.5/28.8)		(26.4/21.4)	(12.0/21.7)
	3(4.0)			3(3.9)	1(1.0)
E2E4	0/3	0	NS	0/3	1/0	NS
	(0/8.9)			(0/7.2)	(2.0/0)
	10(13.5)	16(17.4)		10(13.2)	16(16.7)
E3E4	7/3	8/8	NS	4/6	10/6	NS
	(17.5/8.8)	(20.0/15.5)		(11.8/14.3)	(20.0/13.0)
	16(10.8)	24(13.0)		21(13.8)	19(9.9)
E2	8/8	5/19	NS	9/12	7/12	NS
	(10.0/11.8)	(6.3/18.3)		(13.2/14/3)	(7.0/13.0)
	119(80.4)	144(78.3)		118(77.6)	154(80.2)
E3	65/54	67/77	NS	55/63	82/72	NS
	(81.3/79.4)	(83.7/74.0)		(80.9/75.0)	(82.0/78.3)
	13(8.8)	16(8.7)		13(8.6)	19(9.9)
E4	7/6	8/8	NS	4/9	11/8	NS
	(8.7/8.8)	(10.0/7.7)		(5.9/10.7)	(11.0/8.7)
Total	148 (100)	184(100)		152(100)	192(100)
chromosomes	80/68	40/104		68/84	100/92
	(54.1/45.9)	(43.5/56.5)		(44.7/55.3)	(52.1/47.9)

NS, not significant (P value > 0.05)