. Author manuscript; available in PMC: 2013 Aug 1.

Published in final edited form as: Obesity (Silver Spring). 2010 Jun 10;19(2):283–291. doi: 10.1038/oby.2010.115

Table 2.

Multivariate associations of body composition with total IMAT in all control and HIV-infected participants

Body composition measure (per doubling)	Controls (n = 211)	HIV⁺ (n = 425)
	Adjusted R² = 0.510	Adjusted R² = 0.539
	% Estimate^a (95% CI)	% Estimate^a (95% CI)
SM^b	21.5 (−13.5, 71.7), P = 0.27	−46.9 (−61.0, −27.6), P < 0.0001
VAT	23.6 (11.3, 35.9), P < 0.0001	42.8 (30.5, 56.2), P < 0.0001
Upper-trunk SAT	15.6 (−1.7, 37.0), P = 0.071	31.2 (10.7, 55.5), P = 0.0018
Lower-trunk SAT	−17.8 (−33.3, 2.7), P = 0.080^c	1.8 (−15.3, 22.4), P = 0.85^c
Leg SAT	12.5 (−2.1, 27.2), P = 0.10	65.3 (46.4, 86.6), P < 0.0001
Arm SAT	−2.3 (−24.9, 25.0), P = 0.77^c	5.2 (−15.5, 31.0), P = 0.65^c

IMAT is height-normalized and log-transformed; results are back-transformed to calculate percent effects. Body composition measures are log₂ transformed. Models also control for demographic and lifestyle factors. HIV⁺ model with HIV-related factors shows similar associations for MRI and other factors.

Factors did not enter into the model above, but are shown controlling for other factors in the model. Significant P values are shown in boldface.

CI, confidence interval; HIV, human immunodeficiency virus; IMAT, intermuscular adipose tissue; MRI, magnetic resonance imaging; SAT, subcutaneous adipose tissue; SM, skeletal muscle; VAT, visceral adipose tissue.

Associations with IMAT are as percent per doubling of each depot.

Test for HIV × SM interaction, P = 0.003.