Table 4.
Multivariable associations of body composition with HOMA and triglycerides by HIV status
| Body composition measure (per doubling)a | HOMA
|
Triglycerides
|
||
|---|---|---|---|---|
| Control, % estimate (95% CI) | HIV+, % estimate (95% CI) | Control, % estimate (95% CI) | HIV+, % estimate (95% CI) | |
| VAT | 27.2 (7.1, 51.0), P = 0.0060 | 20.7 (10.6, 31.8), P < 0.0001 | 46.9 (31.1, 64.6), P < 0.0001 | 22.0 (16.2, 28.1), P < 0.0001 |
| Upper-trunk IMAT | 4.6 (−3.8, 13.8), P = 0.30 | 6.0 (−1.5, 14.2), P = 0.12 | 17.4 (5.5, 30.6), P = 0.0033 | −3.0 (−6.7, 0.9), P = 0.13 |
| Upper-trunk SAT | 30.8 (3.7, 64.9), P = 0.023 | 49.0 (30.8, 69.8), P < 0.0001 | 21.8 (−3.3, 53.3), P = 0.094 | 6.4 (−5.4, 19.6), P = 0.30 |
| Lower-trunk IMAT | 3.7 (−8.8, 17.9), P = 0.58 | −12.7 (−17.3, −7.9), P < 0.0001 | −26.1 (−37.3, −13.0), P = 0.00028 | −2.8 (−7.1, 1.7), P = 0.22 |
| Lower-trunk SAT | 10.0 (−10.6, 35.3), P = 0.37 | −3.7 (−17.2, 12.0), P = 0.63 | 12.3 (−9.9, 39.9), P = 0.30 | 9.7 (−1.7, 22.4), P = 0.099 |
| Leg IMAT | 0.7 (−9.0, 11.4), P = 0.89 | 2.6 (−6.5, 12.5), P = 0.59 | −4.6 (−18.0, 11.0), P = 0.54 | −3.3 (−8.0, 1.7), P = 0.19 |
| Leg SAT | −1.0 (−18.2, 19.9), P = 0.92 | −11.1 (−22.0, 1.3), P = 0.078 | −25.0 (−36.9, −10.8), P = 0.0012 | −20.0 (−26.6, −12.7), P < 0.0001 |
Each model controls for demographics, lifestyle factors, HIV-related factors, VAT, SAT, and IMAT. Factors with P > 0.05 did not enter into the model above, but are shown controlling for other factors in the model. Significant P values are shown in boldface.
CI, confidence interval; HOMA, homeostatis model assessment; HIV, human immunodeficiency virus; IMAT, intermuscular adipose tissue; SAT, subcutaneous adipose tissue; VAT, visceral adipose tissue.
a
Measures are height-normalized and log2-transformed; results are back-transformed to calculate percent effects.